Hydromagnesiation of 1,3-enynes by magnesium hydride for synthesis of tri- and tetra-substituted allenes.

Hydromagnesiation of 1,3-enynes by magnesium hydride for synthesis of tri- and tetra-substituted allenes.
Angew Chem Int Ed Engl. 2020 Sep 16;:
Authors: Wang B, Li Y, Pang JH, Watanabe K, Takita R, Chiba S
Abstract
A protocol for regio-controlled hydromagnesiation of 1,3-enynes was developed using magnesium hydride that is generated in situ by solvothermal treatment of sodium hydride (NaH) and magnesium iodide (MgI 2 ) in THF. The resulting allenylmagnesium species could be converted into tri- and tetra-substituted allenes by subsequent treatment with various carbon- and silicon-based electrophiles with the aid of CuCN as a catalyst.
PMID: 32936502 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - September 15, 2020 Category: Chemistry Authors: Wang B, Li Y, Pang JH, Watanabe K, Takita R, Chiba S Tags: Angew Chem Int Ed Engl Source Type: research