Biomarkers of Metabolic Disorders and Neurobehavioral Diseases in a PCB- Exposed Population: What We Learned and the Implications for Future Research.

Biomarkers of Metabolic Disorders and Neurobehavioral Diseases in a PCB- Exposed Population: What We Learned and the Implications for Future Research. Environ Res. 2020 Sep 13;:110211 Authors: Simhadri JJ, Loffredo CA, Trnovec T, Murinova LP, Nunlee-Bland G, Koppe JG, Schoeters G, Jana SS, Ghosh S Abstract Polychlorinated biphenyls (PCBs) are one of the original twelve classes of toxic chemicals covered by the Stockholm Convention on Persistent Organic Pollutants (POP), an international environmental treaty signed in 2001. PCBs are present in the environment as mixtures of multiple isomers at different degree of chlorination. These compounds are manmade and possess useful industrial properties including extreme longevity under harsh conditions, heat absorbance, and the ability to form an oily liquid at room temperature that is useful for electrical utilities and in other industrial applications. They have been widely used for a wide range of industrial purposes over the decades. Despite a ban in production in 1979 in the US and many other countries, they remain persistent and ubiquitous in environment as contaminants due to their improper disposal. Humans, independent of where they live, are therefore exposed to PCBs, which are routinely found in random surveys of human and animal tissues. The prolonged exposures to PCBs have been associated with the development of different diseases and disorders, and they are classified as endocrin...
Source: Environmental Research - Category: Environmental Health Authors: Tags: Environ Res Source Type: research