APRPG modified nanoliposome loaded with miR-146a-5p inhibitor suppressed choroidal neovascularization by targeting endothelial cells.

Conclusions: ANL-miR-146a-5p inhibitor can more effectively down-regulate the expression level of VEGF through its targeting to endothelial cells, thereby more effectively inhibiting endothelial cell proliferation, migration, tube formation, and mice CNV formation.
PMID: 32928013 [PubMed - as supplied by publisher]

Source: Cutaneous and Ocular Toxicology - September 13, 2020 Category: Toxicology Authors: Li L, Lai K, Li C, Gong Y, Xu F, Zhao H, Zhou L, Huang C, Jin C Tags: Cutan Ocul Toxicol Source Type: research