SLC30A7 has anti-oxidant stress effects in high glucose-induced apoptosis via the NFE2L2/HMOX1 signal transduction pathway

Diabetic kidney disease (DKD) develops in 30-40% of patients and is the leading cause of chronic kidney disease and end-stage renal failure, which is an increased enormous social and economic burden [1]. Clinically, DKD is defined as a progressive impairment of kidney function, which usually shows increased serum creatinine or calculated glomerular filtration rate (GFR) and increased excretion of albumin and protein (24-h urinary albumin excretion>300 mg) [2]. Evidence has demonstrated that glomerular injury may initiate kidney injury while tubular injury plays a pivotal role in the process of DKD [3].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research