Effects of blocking mGluR5 on primate dorsolateral prefrontal cortical neuronal firing and working memory performance

ConclusionsThe mixed effects of MTEP on cognitive performance may arise from opposing actions at pre- vs. post-synaptic mGluR5 in dlPFC. These data from monkeys suggest that future clinical trials should include low doses, and identification of potential subgroup responders.
Source: Psychopharmacology - Category: Psychiatry Source Type: research