A biaryl sulfonamide derivative as a novel inhibitor of filovirus infection

Publication date: Available online 15 September 2020Source: Antiviral ResearchAuthor(s): Mao Isono, Wakako Furuyama, Makoto Kuroda, Tatsunari Kondoh, Manabu Igarashi, Masahiro Kajihara, Reiko Yoshida, Rashid Manzoor, Kosuke Okuya, Hiroko Miyamoto, Heinz Feldmann, Andrea Marzi, Masahiro Sakaitani, Asuka Nanbo, Ayato Takada
Source: Antiviral Therapy - Category: Virology Source Type: research

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Publication date: Available online 29 August 2019Source: Antiviral ResearchAuthor(s): Antonello Pessi, Sandra L. Bixler, Veronica Soloveva, Sheli Radoshitzky, Cary Retterer, Tara Kenny, Rouzbeh Zamani, Glenn Gomba, Dima Gharabeih, Jay Wells, Kelly S. Wetzel, Travis K. Warren, Ginger Donnelly, Sean A. Van Tongeren, Jesse Steffens, Allen J. Duplantier, Christopher D. Kane, Pascale Vicat, Valerie Couturier, Kent E. KesterAbstractThe Filoviridae family consists of five ebolavirus species, Ebola (EBOV), Sudan (SUDV), Bundibugyo virus (BDBV), Reston (RESTV), and Taï Forest (TAFV) viruses, and a Marburgvirus species, with Ma...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 26 July 2019Source: Antiviral ResearchAuthor(s): Lisa Wendt, Linus Bostedt, Thomas Hoenen, Allison GrosethAbstractViral hemorrhagic fevers (VHFs) cause thousands of fatalities every year, but the treatment options for their management remain very limited. In particular, the development of therapeutic interventions is restricted by the lack of commercial viability of drugs targeting individual VHF agents. This makes approaches like drug repurposing and/or the identification of broad range therapies (i.e. those directed at host responses or common proviral factors) highly attractive. Howeve...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 21 June 2019Source: Antiviral ResearchAuthor(s): Ariane J. Brown, John J. Won, Rachel L. Graham, Kenneth H. Dinnon, Amy C. Sims, Joy Y. Feng, Tomas Cihlar, Mark R. Denison, Ralph S. Baric, Timothy P. SheahanAbstractThe genetically diverse Orthocoronavirinae (CoV) family is prone to cross species transmission and disease emergence in both humans and livestock. Viruses similar to known epidemic strains circulating in wild and domestic animals further increase the probability of emergence in the future. Currently, there are no approved therapeutics for any human CoV presenting a clear unmet ...
Source: Antiviral Therapy - Category: Virology Source Type: research
This study expands our understanding of MOAs of these compounds for the Filovirus family and provides further evidence that lethal mutagenesis could be a preponderant MOA for this class of therapeutic compounds.
Source: Antiviral Therapy - Category: Virology Source Type: research
In this study, ferrets were challenged with 1260 TCID50 of wild type RESTV either intramuscularly or intranasally and monitored for clinical signs, survival, virus replication, alteration in serum biochemistry and blood cell counts. Irrespective of the route of challenge, viremia occurred in all ferrets on day 5 post-infection, and all animals succumbed to infection between days 9 and 11. Additionally, several similarities were observed between this model and the other ferret models of filovirus infection, including substantial decreases in lymphocyte and platelet counts and abnormalities in serum biochemistry indicating h...
Source: Antiviral Therapy - Category: Virology Source Type: research
This report summarizes the lectures held at the meeting and highlights advances in the field.
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 11 December 2018Source: Antiviral ResearchAuthor(s): Christopher F. Basler, Nevan J. Krogan, Daisy W. Leung, Gaya K. AmarasingheAbstractFiloviruses, which include Ebola virus and Marburg virus, are negative-sense RNA viruses associated with sporadic outbreaks of severe viral hemorrhagic fever characterized by uncontrolled virus replication. The extreme virulence and emerging nature of these zoonotic pathogens make them a significant threat to human health. Replication of the filovirus genome and production of viral RNAs requires the function of a complex of four viral proteins, the nucleo...
Source: Antiviral Therapy - Category: Virology Source Type: research
In this report we identify common over the counter antihistamines, such as diphenhydramine (Benadryl) and chlorcyclizine (Ahist) as potential candidates for repurposing as anti-filovirus agents. Furthermore, we demonstrate that this potential is wide-spread through the 1st generation of H1-specific antihistamines but is not present in newer drugs or drugs targeting H2, H3 and H4 receptors. We showed that the filovirus entry inhibition is not dependent on the classical antagonism of cell surface histamine or muscarinic acetylcholine receptors but occurs in the endosome, like the cathepsin inhibitor CA-074. Finally, using ex...
Source: Antiviral Therapy - Category: Virology Source Type: research
In this study, we evaluated the antiviral activity of the nucleoside analog 4′-azidocytidine (4′N3-C, R1479) and its 2′-monofluoro- and 2′-difluoro-modified analogs (2′F-4′N3-C and 2′diF-4′N3-C) against representative paramyxoviruses (Nipah virus, Hendra virus, measles virus, and human parainfluenza virus 3) and filoviruses (Ebola virus, Sudan virus, and Ravn virus). We observed enhanced antiviral activity against paramyxoviruses with both 2′diF-4′N3-C and 2′F-4′N3-C compared to R1479. On the other hand, while R1479 and 2′diF-4′N3-C inhibit...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: March 2018 Source:Antiviral Research, Volume 151 Author(s): Wenjun Zhu, Zirui Zhang, Shihua He, Gary Wong, Logan Banadyga, Xiangguo Qiu Filoviruses, such as Marburg and Ebola viruses, cause severe disease in humans with high case fatality rates and are therefore considered biological threat agents. To date, no licensed vaccine or therapeutic exists for their treatment. T-705 (favipiravir) is a pyrazinecarboxamide derivative that has shown broad antiviral activity against a number of viruses and is clinically licenced in Japan to treat influenza. Here we report the efficacy of T-705 against Marburg virus ...
Source: Antiviral Therapy - Category: Virology Source Type: research
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