Reduced Monocytic Human Leukocyte Antigen-DR Expression Indicates Immunosuppression in Critically Ill COVID-19 Patients.

CONCLUSIONS: When compared to noncritically ill hospitalized COVID-19 patients, ICU patients with severe COVID-19 disease showed reduced mHLA-DR expression on circulating CD14+ monocytes at ICU admission, indicating a dysfunctional immune response. This immunosuppressive (monocytic) phenotype remained unchanged over the ensuing days after ICU admission. Strategies aiming for immunomodulation in this population of critically ill patients should be guided by an immune-monitoring program in an effort to determine who might benefit best from a given immunological intervention. PMID: 32925314 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research

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Conclusions: Early results of universal preoperative screening for COVID-19 demonstrates a low incidence and high rate of asymptomatic patients. Health care professionals, especially those at higher risk for the virus, should be aware of the challenges related to screening based solely on symptoms or travel history and consider universal screening for patients undergoing elective surgery. Level of Evidence: Level II.
Source: Journal of Pediatric Orthopaedics - Category: Orthopaedics Tags: Infection Source Type: research
The International Journal of Obstetric Anesthesia (IJOA) is pleased to publish the best 110 abstracts that were submitted for presentation at the annual scientific meeting (ASM) of the Obstetric Anaesthetists ’ Association (OAA) in Birmingham. At the time of writing, the world is facing a unique challenge due to COVID-19 (coronavirus disease). Normal life has been put on hold as we rise to meet these challenges, and the OAA has decided to cancel this year’s ASM.
Source: International Journal of Obstetric Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
ConclusionsIn this mannequin-based simulation study, the use of the aerosol box increased the time to intubation in some contexts but not others. Further studies in a clinical setting should be conducted to make appropriate modifications to the aerosol box to fully elicit its efficacy and safety prior to implementation in airway guidelines for managing patients with COVID-19.
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
Imagine finishing a long shift in the operating room performing aerosolizing procedures on high-risk patients with coronavirus disease 2019 (COVID-19). You are walking home, and the next thing you know, a stranger confronts you on the sidewalk shouting, “Why are you Chinese people killing everyone? What is wrong with you? Why the [expletive] are you killing us?” This is exactly what happened to an Asian American anesthesia resident in Boston recently [1]. These incidents are unfortunately becoming more frequent and should not go unnoticed nor w ithout a safe and appropriate response.
Source: Journal of the American College of Radiology : JACR - Category: Radiology Authors: Tags: Opinion Source Type: research
CONCLUSION: Drilling and microdebrider use during endonasal surgery in a standard operating room is associated with a significant increase in airborne particle concentrations. Fortunately, this increase in aerosol concentration is localized to the area of the operating surgeon, with no detectable increase in aerosol particles at other OR positions. PMID: 33012174 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - Category: ENT & OMF Authors: Tags: Am J Rhinol Allergy Source Type: research
Severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19) that may lead to acute respiratory failure. In its most severe manifestation including refractory hypoxemia and/or hypercapnia, it can require escalation to extracorporeal membrane oxygenation (ECMO). Rates of thromboembolic complications are elevated in COVID-19 patients despite deployment of thromboprophylaxis.1 Amongst the sickest COVID-19 patients requiring ECMO, much less is known regarding hemostatic derangements as well as the resulting risk profile for the development of both thromboembolic as and hemorrhagic complications.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
Digital media&downloads Pain Relief Caused by SARS-CoV-2 Infection May Help Explain COVID-19 Spread New research shows SARS-CoV-2 promotes pain relief when it infects cells through a common protein receptor, neuropilin-1. The finding gives scientists a novel target for non-opioid pain therapeutics, while also offering an explanation for the unrelenting spread of COVID-19. Stacy Pigott Today University of Arizona Health SciencesKhanna_Raj_klh3067.jpg Doctoral student Lisa Boinon prepares buffers while Rajesh Khanna looks on. (Photo: Kris Hanning/University of Arizona Health Sciences)HealthCollege of Medicine - Tuc...
Source: The University of Arizona: Health - Category: Universities & Medical Training Authors: Source Type: research
Kirubanand Senniappan, Salome Jeyabalan, Pradeep Rangappa, Muralidhar KanchiIndian Journal of Anaesthesia 2020 64(10):835-841 The coronavirus disease 2019 (COVID-19) is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Although 85% of infected patients remain asymptomatic, 5% show severe symptoms such as hypoxaemic respiratory failure and multiple end organ dysfunction (MODS) requiring intensive care unit (ICU) admission with a mortality rate of about 2.8%. Since a definitive treatment is yet to be identified, preventive and supportive strategies remain the mainstay of managemen...
Source: Indian Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research
Am J Perinatol DOI: 10.1055/s-0040-1718403 Objective The study aimed to compare the quantitative blood loss (QBL) and hemorrhage-related outcomes of pregnant women with and without a coronavirus disease 2019 (COVID-19) diagnosis. Study Design This retrospective cohort study of all live deliveries at Boston Medical Center between April 1, 2020 and July 22, 2020 compares the outcomes of pregnant women with a laboratory-confirmed COVID-19 positive diagnosis and pregnant women without COVID-19. The primary outcomes are QBL and obstetric hemorrhage. The secondary outcomes analyzed were a maternal composite outco...
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
To explore special coagulation characteristics and anticoagulation management in extracorporeal membrane oxygenation (ECMO) –assisted patients with coronavirus disease 2019 (COVID-19).
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Special Article Source Type: research
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