Generation and Characterization of a New Resistance to Thyroid Hormone Mouse Model with Thyroid Hormone Receptor Alpha Gene Mutation.

Conclusions The Thrα1E403X/+ mice faithfully recapitulate clinical features of human RTHα, and thus can provide a useful tool to dissect the role of TRα1 in development and to determine the pathological mechanisms of RTHα. PMID: 32924834 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research