White matter fiber microstructure is associated with prior hospitalizations rather than acute symptomatology in major depressive disorder.

CONCLUSIONS: Decreased FA and increased MD and RD values in the SLF are associated with more hospitalizations when controlling for current psychopathology. SLF fiber integrity could reflect cumulative illness burden at a neurobiological level and should be targeted in future longitudinal analyses. PMID: 32921338 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32921338?dopt=Abstract

Source: Psychological Medicine - September 13, 2020 Category: Psychiatry Authors: Meinert S, Leehr EJ, Grotegerd D, Repple J, Förster K, Winter NR, Enneking V, Fingas SM, Lemke H, Waltemate L, Stein F, Brosch K, Schmitt S, Meller T, Linge A, Krug A, Nenadić I, Jansen A, Hahn T, Redlich R, Opel N, Schubotz RI, Baune BT, Kircher T, Dan Tags: Psychol Med Source Type: research