Progranulin as a Potential Contributor to Improved Adipose Tissue Function after Gastric Bypass

In people with obesity and severe obesity, hypertrophic white adipose tissue (WAT) starts resisting its main biological function, fat storage, as to prevent further adipocyte architectural damage. This is a WAT self-preservation mechanism and involves release of adipokines that contribute to local and systemic low-grade inflammation, chronic insulin resistance, and impaired glucose and lipid homeostasis. Roux-en-Y gastric bypass surgery (RYGB) and other current bariatric techniques are proven to provide for significant long-term reductions in body weight and fat mass in the majority of patients, which can reverse WAT dysfunction and obesity-related cardiometabolic disease.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research

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Superior mesenteric artery (SMA) syndrome, Wilkie ’s or Cast Syndrome is a rare disease which was first described in 1842. It is seen in patients most often after dramatic weight loss due to starvation, burns, anorexia nervosa, or after bariatric surgery.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: VIDEO CASE REPORT Source Type: research
Authors: Boru CE, Termine P, Antypas P, Iossa A, Ciccioriccio MC, De Angelis F, Micalizzi A, Silecchia G Abstract BACKGROUND: Hiatal hernia repair (HHR) is still controversial during bariatric procedures, especially in case of laparoscopic sleeve gastrectomy (LSG). AIMS: to report the long-term results of concomitant HHR, evaluating the safety and efficacy of posterior cruroplasty (PC), simple or reinforced with biosynthetic, absorbable Bio-A® mesh (Gore, USA). Primary endpoint: PC's failure, defined as symptomatic HH recurrence, nonresponding to medical treatment and requiring revisional surgery. METHO...
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
Roux-en-Y gastric bypass (RYGB) affords a long-term, durable approach to the management of diabetes mellitus (DM) in morbidly obese patients. Nevertheless, patients with DM are at an increased risk for 30-day wound events and additional morbidity and mortality compared with patients without DM. The purpose of our study was to determine if there is a preoperative glycosylated hemoglobin (HgA1c) target level that can be used as a surrogate for optimization of DM in diabetic patients before RYGB.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Bariatric and foregut Source Type: research
AbstractThis video case report presents a patient with an invasive pancreatic mass and a history of Roux-en-Y gastric bypass surgery who underwent single-session endoscopic ultrasound-directed transgastric ERCP for tissue sampling and biliary stenting with subsequent maintenance of the newly established gastrogastrostomy. The demonstrated technique enables spectrum of endoscopic interventions in gastric bypass patients by facilitating a direct endoscopic passage through the reconnected stomach. Importantly, the method carries a risk of weight regain by essentially reversing the bypass. However, this can be an actual desire...
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionsThe incidence of EE 1  year after SG is greater than GBP. Moreover, not only GBP seems to improve this condition, but also SG tends to worsen EE. These results are to be associated with GERD disease.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
Long-term follow-up with blood-tests is essential for bariatric surgery to be a successful treatment for obesity and related comorbidities. Adverse effects, deficiencies and metabolic improvements need to be controlled. Our objective was to investigate the impact of time and weight-loss on laboratory results in each postoperative phase after laparoscopic Roux-en-Y gastric bypass (LRYGB).
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
Bariatric surgery results in rapid weight loss and resolution of many comorbidities including hypertension.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
Authors: Chamberlain C, Terry R, Shtayyeh T, Martinez C Abstract Bariatric surgery is an effective treatment for patients with morbid obesity. However, as safe and common as bariatric procedures have become, multiple complications can still result. These complications vary depending on the type of procedure performed (malabsorptive or restrictive) and are often nutritional derangements from the altered malabsorptive surface of the gastrointestinal tract and decreased capacity of the stomach. Deficiencies in vitamin D after malabsorptive procedures such as the Roux-en-Y gastric bypass can result in subsequent hypoca...
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
Authors: Clapp B, Liggett E, Ma C, Castro C, Montelongo S, Van Noy K, Dilday J, Tyroch A Abstract Background: Many bariatric surgeons test the anastomosis and staple lines with some sort of provocative test. This can take the form of an air leak test with a nasogastric tube with methylene blue dye or with an endoscopy. The State Department of Health Statistics in Texas tracks outcomes using the Texas Public Use Data File (PUDF). Methods: We queried the Texas Inpatient and Outpatient PUDFs for 2013 to 2017 to examine the number of bariatric surgeries with endoscopy performed at the same time. We used the Interna...
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
In 1997 Rutledge [1] introduced a new bariatric procedure consisting in a single anastomosis gastric bypass which he named “Mini Gastric Bypass” (MGB).
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: VIDEO CASE REPORT Source Type: research
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