Intratumoral submicron particle docetaxel inhibits syngeneic Renca renal cancer growth and increases CD4+, CD8+, and Treg levels in peripheral blood

In this study, the Renca syngeneic murine xenograft model of renal cancer was used to evaluate the effects of intratumoral (IT) submicron particle docetaxel (NanoDoce ®) on tumor growth and immunomodulation. Tumor volume (TV) was compared to controls, including intravenous (IV) chemotherapy. Flow cytometry of peripheral bloods and tumors was used to evaluate immune cell populations. Groups of animals were inoculated with a second Renca tumor at a site distant fr om the primary tumor. IT NanoDoce significantly reduced primary TV and reduced the growth rates of untreated secondary tumors. CD4+, CD8+ and Treg populations were increased in peripheral bloods from animals administered IT NanoDoce. Additional evaluation of the effect of IT NanoDoce on peripheral a nd local immune cell populations as well as the impact on sites of distant tumor growth are warranted.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research

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This article gives an overview of the WHO classification of RCC, showing the histological diversity of nccRCC and focusing particularly on entities first characterized since 2016, their specific molecular behavior and their role as indicators for hereditary cancer syndromes. In this context, we discuss the available data on nccRCC treatment oprtions such as tyrosine kinase inhibitors, mammalian target of rapamycin inhibitors, cytotoxic chemotherapy and immune checkpoint inhibitors.EXPERT OPINION: Although nccRCCs are relatively uncommon, entities of this type account for a subgroup of up to 20-25% of all RCCs. Advances in ...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSION: Inactivation of INI1 may play a role in the pathogenesis of RCC-RF. Erlotinib is recommended in the management of patients with INI1-related RCC.PMID:34243015 | DOI:10.1016/j.tranon.2021.101175
Source: Translational Oncology - Category: Cancer & Oncology Authors: Source Type: research
Brief Bioinform. 2021 May 11:bbab173. doi: 10.1093/bib/bbab173. Online ahead of print.ABSTRACTIncreasing evidences show the clinical significance of the interaction between hypoxia and immune in clear cell renal cell carcinoma (ccRCC) microenvironment. However, reliable prognostic signatures based on a combination of hypoxia and immune have not been well established. Moreover, many studies have only used RNA-seq profiles to screen the prognosis feature of ccRCC. Presently, there is no comprehensive analysis of multiomics data to mine a better one. Thus, we try and get it. First, t-SNE and ssGSEA analysis were used to estab...
Source: Briefings in Bioinformatics - Category: Bioinformatics Authors: Source Type: research
ConclusionIt could contribute to a better understanding of ccRCC tumorigenesis mechanism and guide clinicians to make a more accurate treatment decision.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
CONCLUSIONS: The present study highlights panduratin A has a potential protective effect on cisplatin's nephrotoxicity.PMID:34078815 | DOI:10.1248/bpb.b21-00036
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Source Type: research
ConclusionMachine learning techniques can be implemented to assist patient-centered surgical care and increase patient engagement within their decision-making processes. As data sets improve and expand, especially with the transition to large-scale EHR usage, these tools will improve in efficacy and be utilized more frequently.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
Conclusions: To the best of our knowledge, this is the first case report of perirenal metastases from squamous cell carcinoma of the cervix. Although an uncommon site of distant metastases from cervical cancer, FDG avid soft tissue deposits in the perirenal space should raise suspicion of metastasis, and early biopsy should be done to confirm the diagnosis. Patients with metastatic cervical cancer, including those with perirenal metastasis, have poor outcomes.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Oncology Source Type: research
Med Sci Monit. 2021 May 8;27:e930639. doi: 10.12659/MSM.930639.ABSTRACTRenal cell carcinoma (RCC) is a most common type of urologic neoplasms; it accounts for 3% of malignant tumors, with high rates of relapse and mortality. The most common types of renal cancer are clear cell carcinoma (ccRCC), papillary renal cell carcinoma (pRCC), and chromophobe renal carcinoma (chRCC), which account for 90%, 6-15%, and 2-5%, respectively, of all renal malignancies. Although surgical resection, chemotherapy, and radiotherapy are the most common treatment method for those diseases, their effects remain dissatisfactory. Furthermore, rece...
Source: Medical Science Monitor - Category: Research Authors: Source Type: research
Oncologist. 2021 May 5. doi: 10.1002/onco.13812. Online ahead of print.ABSTRACTBACKGROUND: We investigated the association between adverse events (AEs) suspected to be immune-related and healthcare resource utilization (HCRU), costs, and mortality among patients receiving PD-1/PD-L1 immune checkpoint inhibitor (ICI) monotherapy for urothelial carcinoma, renal cell carcinoma, non-small cell lung cancer, or Merkel cell carcinoma.PATIENTS AND METHODS: Retrospective cohort study using medical and pharmacy claims and enrollment information from US commercial and Medicare Advantage with Part D enrollees in the Optum Research Dat...
Source: The Oncologist - Category: Cancer & Oncology Authors: Source Type: research
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