The clinical value and potential molecular mechanism of the downregulation of MAOA in hepatocellular carcinoma tissues

ConclusionsA decreasedMAOA level is not only correlated with aggressive behaviors in males but also serves as a promising biomarker for the diagnosis and prognosis of HCC patients. Moreover,MAOA may play a role in AFB1 toxic transformation through its synergistic action with co ‐expressed genes, especially CYP3A4.MAOA also serves as a potential therapy target of NC in HCC patients.

Source: Cancer Medicine - September 14, 2020 Category: Cancer & Oncology Authors: Yu ‐Yan Pang, Jian‐Di Li, Li Gao, Xia Yang, Yi‐Wu Dang, Ze‐Feng Lai, Li‐Min Liu, Jie Yang, Hua‐Yu Wu, Rong‐Quan He, Zhi‐Guang Huang, Dan‐Dan Xiong, Li‐Hua Yang, Lin Shi, Wei‐Jia Mo, Deng Tang, Hui‐Ping Lu, Gang Che Tags: ORIGINAL RESEARCH Source Type: research