Recent progress in chemical synthesis of bacterial surface glycans.

Recent progress in chemical synthesis of bacterial surface glycans.
Curr Opin Chem Biol. 2020 Sep 10;58:121-136
Authors: Li R, Yu H, Chen X
Abstract
With the continuing advancement of carbohydrate chemical synthesis, bacterial glycomes have become increasingly attractive and accessible synthetic targets. Although bacteria also produce carbohydrate-containing secondary metabolites, our review here will cover recent chemical synthetic efforts on bacterial surface glycans. The obtained compounds are excellent candidates for the development of improved structurally defined glycoconjugate vaccines to combat bacterial infections. They are also important probes for investigating glycan-protein interactions. Glycosylation strategies applied for the formation of some challenging glycosidic bonds of various uncommon sugars in a number of recently synthesized bacterial surface glycans are highlighted.
PMID: 32920523 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - September 9, 2020 Category: Biochemistry Authors: Li R, Yu H, Chen X Tags: Curr Opin Chem Biol Source Type: research