Challenges and Opportunities of Genomic Approaches in Therapeutics Development.
Challenges and Opportunities of Genomic Approaches in Therapeutics Development.
Methods Mol Biol. 2021;2194:107-126
Authors: Gray JS, Campbell MJ
Abstract
The magnitude of all therapeutic responses is significantly determined by genome structure, variation, and functional interactions. This determination occurs at many levels which are discussed in the current review. Well-established examples of structural variation between individuals are known to dictate an individual's response to numerous drugs, as clearly illustrated by warfarin. The exponential rate of genomic-based interrogation is coupled with an expanding repertoire of genomic technologies and applications. This is leading to an ever more sophisticated appreciation of how structural variation, regulation of transcription and genomic structure, both individually and collectively, define cell therapeutic responses.
PMID: 32926364 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Gray JS, Campbell MJ Tags: Methods Mol Biol Source Type: research