Linderolide U, a new sesquiterpene from Lindera aggregata root.

Linderolide U, a new sesquiterpene from Lindera aggregata root. Nat Prod Res. 2020 Sep 14;:1-5 Authors: Yang HJ, Kwon EB, Li W Abstract A new sesquiterpene, namely linderolide U (1), was isolated from the root of Lindera aggregata (Sims) Kosterm along with five known sesquiterpenes (2-6). The structures of the obtained compounds were identified by spectroscopic methods, specifically nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). The acquired data were compared with those previously reported in the literature. The anticancer effects of the isolated natural products were studied using the HCT116 human colon cancer cell line. Compound 5 was found to significantly suppress cell proliferation, which was associated with induction of apoptosis and cell cycle arrest (G2/M and S phase). The findings of the present study suggest derivative 5 as a potential agent for the treatment of colon cancer. PMID: 32924622 [PubMed - as supplied by publisher]
Source: Natural Product Research - Category: Biochemistry Authors: Tags: Nat Prod Res Source Type: research