Characterization and validation of a preventative therapy for hypertrophic cardiomyopathy in a murine model of the disease [Physiology]
Currently there is an unmet need for treatments that can prevent hypertrophic cardiomyopathy (HCM). Using a murine model we previously identified that HCM causing cardiac troponin I mutation Gly203Ser (cTnI-G203S) is associated with increased mitochondrial metabolic activity, consistent with the human condition. These alterations precede development of the cardiomyopathy. Here...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Helena M. Viola, Ashay A. Shah, Victoria P. A. Johnstone, Henrietta Cserne Szappanos, Mark P. Hodson, Livia C. Hool Tags: Biological Sciences Source Type: research
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