CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis [Neuroscience]

The small GTPase ARL4C participates in the regulation of cell migration, cytoskeletal rearrangements, and vesicular trafficking in epithelial cells. The ARL4C signaling cascade starts by the recruitment of the ARF–GEF cytohesins to the plasma membrane, which, in turn, bind and activate the small GTPase ARF6. However, the role of ARL4C–cytohesin–ARF6...

Source: Proceedings of the National Academy of Sciences - September 14, 2020 Category: Science Authors: Jisoo S. Han, Keiko Hino, Wenzhe Li, Raenier V. Reyes, Cesar P. Canales, Adam M. Miltner, Yasmin Haddadi, Junqing Sun, Chao–Yin Chen, Anna La Torre, Sergi Simo Tags: Biological Sciences Source Type: research