Dark noise and retinal degeneration from D190N-rhodopsin [Neuroscience]

Numerous rhodopsin mutations have been implicated in night blindness and retinal degeneration, often with unclear etiology. D190N-rhodopsin (D190N-Rho) is a well-known inherited human mutation causing retinitis pigmentosa. Both higher-than-normal spontaneous-isomerization activity and misfolding/mistargeting of the mutant protein have been proposed as causes of the disease, but neither explanation has been...

Source: Proceedings of the National Academy of Sciences - September 14, 2020 Category: Science Authors: Daniel Silverman, Zuying Chai, Wendy W. S. Yue, Sravani Keerthi Ramisetty, Sowmya Bekshe Lokappa, Kazumi Sakai, Rikard Frederiksen, Parinaz Bina, Stephen H. Tsang, Takahiro Yamashita, Jeannie Chen, King-Wai Yau Tags: Biological Sciences Source Type: research