A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis [Immunology and Inflammation]

Central nervous system B cells have several potential roles in multiple sclerosis (MS): secretors of proinflammatory cytokines and chemokines, presenters of autoantigens to T cells, producers of pathogenic antibodies, and reservoirs for viruses that trigger demyelination. To interrogate these roles, single-cell RNA sequencing (scRNA-Seq) was performed on paired cerebrospinal fluid...

Source: Proceedings of the National Academy of Sciences - September 14, 2020 Category: Science Authors: Akshaya Ramesh, Ryan D. Schubert, Ariele L. Greenfield, Ravi Dandekar, Rita Loudermilk, Joseph J. Sabatino Jr, Matthew T. Koelzer, Edwina B. Tran, Kanishka Koshal, Kicheol Kim, Anne–Katrin Probstel, Debarko Banerȷi, University of California, Tags: Biological Sciences Source Type: research