Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae [Applied Biological Sciences]
A Cas9/guide RNA-based gene drive strain, AgNosCd-1, was developed to deliver antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae. The drive system targets the cardinal gene ortholog producing a red-eye phenotype. Drive can achieve 98 to 100% in both sexes and full introduction was observed in small cage...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Rebeca Carballar–Leȷarazu, Christian Ogaugwu, Taylor Tushar, Adam Kelsey, Thai Binh Pham, Jazmin Murphy, Hanno Schmidt, Yoosook Lee, Gregory C. Lanzaro, Anthony A. James Tags: Biological Sciences Source Type: research