Peptide-Mimicking Poly(2-oxazoline)s Displaying Potent Antimicrobial Properties.
Peptide-Mimicking Poly(2-oxazoline)s Displaying Potent Antimicrobial Properties. ChemMedChem. 2020 Sep 14;: Authors: Zhou M, Jiang W, Xie J, Zhang W, Ji Z, Zou J, Cong Z, Xiao X, Gu J, Liu R Abstract Poly(2-oxazoline)s have excellent biocompatibility and have been used as a FDA-approved indirect food additive. The inert property of the hydrophilic poly(2-oxazoline)s suggests them as promisingsubstitution of PEG in variable applications such as resisting biofouling. Recently, Liu group reported that poly(2-oxazoline)s themselves have antimicrobial properties as synthetic mimics of host defense peptides. These studies revealed the bioactive properties of poly(2-oxazoline)s as a new class of functional peptide mimics, by mimicking host defense peptide to display potent and selective antimicrobial activities against methicillin-resistant Staphylococcus aureus both in vitro and in vivo, without concerns on antimicrobial resistance. The high structural diversity, easy synthesis, potent and tunable antimicrobial properties imply great potential of poly(2-oxazoline)s as a class of novel antimicrobial agents in dealing with drug-resistant microbial infections and antimicrobial resistance. PMID: 32926562 [PubMed - as supplied by publisher]
ConclusionOur findings reveal a distinct susceptibility pattern across the various study regions in Africa, with notably high rates of ESBL-producing Enterobacterales and ciprofloxacin-resistant nt Salmonella in Burkina Faso. This highlights the need for local AMR surveillance and reporting of resistances to support appropriate action.
Abstract Staphylococcus aureus is an opportunistic pathogen leading to food poisoning as well as human infections. The present study examined the prevalence and characterization of antimicrobial-resistant S. aureus in sushi from 42 outlets and in pork products from eight outlets in Beijing, China. The total bacterial counts were between 3.0 and 8.9 log CFU/g (mean 5.5 ± 1.5 log CFU/g) in sushi products and 4.8 to 7.4 log CFU/g (mean 5.6 ± 0.8 log CFU/g) in pork products. The mean counts of coliforms were 2.7 and 2.9 log CFU/g in su...
Publication date: December 2020Source: Journal of Global Antimicrobial Resistance, Volume 23Author(s): P. Moreno Mochi, J.M. Vargas, S. Vivaldo, M. Bottiglieri, C. López, S. Mochi, M. Cobos, M. Castillo, R. del Campo, M.A. Jure
In this study, a wide genetic diversity of strains of S. aureus from different foods, humans, and animals was found. This demonstrates evolution, genetic versatility, and, therefore, the adaptation of this microorganism in different environments. PMID: 32908519 [PubMed]
BackgroundFebrile illness is the commonest cause of hospitalization in children four million genomes/μL) of P. falciparum in plasma. Overall, in-hospital death was 4% (89/2,146), and it was higher in children with bacteraemia (8%, 18/227) than malaria (2%, 4/194, p = 0.007). Risk factors for death were bacteraemia (p = 0.03), unconsciousness at admission (p
Authors: Lupia T, Corcione S, Mornese Pinna S, De Rosa FG Abstract The burden of hospital admission for pneumonia in internal medicine wards may not be underestimated; otherwise, cases of pneumonia are a frequent indication for antimicrobial prescriptions. Community- and hospital-acquired pneumonia are characterized by high healthcare costs, morbidity and non-negligible rates of fatality. The overcoming prevalence of resistant gram-negative and positive bacteria (e.g., methicillin-resistant Staphylococcus aureus, penicillin and ceftriaxone-resistant Streptococcus pneumoniae, extended-spectrum β-lactamases and ...
ConclusionsAn increased fosfomycin resistance rate of MRSA isolates was observed in our present study, mostly due to mutations in theglpT anduhpT genes. Clonal spread probably contributed to the increased fosfomycin resistance.
Abstract Staphylococcus pseudintermedius causes opportunistic infections in dogs. It also has significant zoonotic potential, with the emergence of multidrug-resistance leading to difficulty treating both animal and human infections. Manuka honey has previously been reported to inhibit many bacterial pathogens including methicillin resistant Staphylococcus aureus and is successfully utilised in both clinical and veterinary practice. Here we evaluated the ability of manuka honey to inhibit strains of S. pseudintermedius growth alone and in combination with antibiotics, and its capacity to modulate virulence within ...
AbstractBackgroundNasal carriage of methicillin-resistantStaphylococcus aureus (MRSA) is associated with an increased risk of infection. Colonization with MRSA is observed in
ConclusionThe multiple-LAMP-LFB technique developed in the current study is a reliable, simple, rapid, specific and sensitive method to identify MSSA and MRSA infections for appropriate antibiotic therapy.