Low-expressed GAS5 injure myocardial cells and progression of chronic heart failure via regulation of miR-223-3P.

In this study, the expression of GAS5 and miR-223-3p in peripheral blood of CHF patients and healthy subjects was first detected, GAS5 was low in CHF while miR-223-3p was high (P < 0.05). Subsequently, ROC curve analysis showed that GAS5 and miR-223-3p had good predictive value for the occurrence and recurrence of CHF. Secondly, through in vitro experiments, we found that inhibition of GAS5 with elevated expression of miR-223-3p decreased the proliferative capacity of cardiomyocytes and increased apoptotic capacity and inflammatory factors (P < 0.050). Through dual luciferase reporter and RNA immunoprecipitation experiment, we found that miR-223-3p was regulated by GAS5 in a targeted manner. PMID: 32926880 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32926880?dopt=Abstract

Source: Experimental and Molecular Pathology - September 10, 2020 Category: Pathology Authors: Li G, Du P, Qiang X, Jin D, Liu H, Li B, Guo J Tags: Exp Mol Pathol Source Type: research