Functional implications of impaired bimanual force coordination in chronic stroke
Publication date: Available online 14 September 2020Source: Neuroscience LettersAuthor(s): Prakruti Patel, Neha Lodha
Conclusion: factors such as severe stroke, dysphagia, advanced age, male gender, coronary heart disease, lower Glasgow coma scale score, use of mechanical ventilation for more than 48 hours, and aspiration of colonized gastric juice were associated with aspiration pneumonia.
Conditions: Stroke; Aphasia; Anomia Interventions: Other: iTALKbetter: deterministic; Other: iTALKbetter: reactive Sponsor: University College, London Recruiting
Conditions: Stroke; CVA (Cerebrovascular Accident); Anxiety; Depression Intervention: Behavioral: Helping Ease Anxiety and Depression following Stroke Sponsor: Glasgow Caledonian University Not yet recruiting
Malignant hyperthermia (MH) and Exertional Heat Stroke (EHS) present hypermetabolic states leading to rhabdomyolysis and muscle rigidity with progressive hyperthermia; MH is triggered by volatile inhaled anesthetics, while EHS is triggered by exercise in hot/humid environment. Given the similarity of clinical features and the fact that a portion of EHS cases were diagnosed as MH susceptible by the in vitro contracture test, MH and EHS are believed to share common etiology. Mutations in RYR1 and CACNA1S have been found to be associated with MH; however the genetic cause remains to be identified in approximately 30% of MH cases.
Mitochondrial DNA A3243G mutation is most common in Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). mtDNA heteroplasmy, i.e. mutant load may contribute to clinical disease severity yet not fully understood. We aimed to investigate the level of blood mtDNA A3243G mutant load in MELAS patients and its correlation with functional scale. Total 25 subject were recruited, who met MELAS clinical criteria, positive for mtDNA A3243G mutation and blood mtDNA mutant load analysis.
ConclusionsConsidering the high risk of both thromboembolic and hemorrhagic events of patients undergoing LAAO, establishment of an appropriate antithrombotic therapy in terms of efficacy and safety after LAAO is of vital importance.Trial registrationEudraCT number: 2018-001013-32
AbstractPurposeOptimal stroke prevention strategies for patients with atrial fibrillation (AF) who experience a major bleed are poorly defined. We sought to estimate the effectiveness and safety of oral anticoagulation (OAC) represcription after an OAC contraindication.MethodsTREAT-AF is a retrospective cohort study of patients with newly diagnosed AF (2004 –2012), treated in the Veterans Health Administration. From this cohort, we identified patients with a contraindication to OAC after AF diagnoses, defined as incident intracranial bleeding, non-intracranial bleeding requiring hospitalization, or unrepaired cerebra...
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Authors: Su Y, Ma M, Zhang H, Pan X, Zhang X, Zhang F, Lv Y, Yan C Abstract Hyponatremia is a risk factor associated with poor prognosis in patients with heart failure (HF) with reduced ejection fraction. However, whether hyponatremia has a similar role in patients with HF with preserved ejection fraction (HFpEF) has remained controversial. Therefore, the present study aimed to investigate the clinical characteristics and 24-month prognostic profile of a cohort of patients with HFpEF in China. From a registered observational cohort study on 1,027 subjects with HF, 496 patients with HFpEF were included. The associat...