Adiaspore development and morphological characteristics in a mouse adiaspiromycosis model

We examined infection with a few spores, which revealed that adiaspores in the mouse lung pro gressed from intratracheal infection of at least 400 spores. Moreover, we developed adiaspores in vitro by culture in fetal bovine serum. Although most spores broke, some large spores were intact. They reached about 50 μm diameter. Thick cell walls and dense granules were found as common points be tween in vitro adiaspores and in vivo adiaspores. These models are expected to be useful for additional investigations ofE. crescens adiaspores and adiaspiromycosis.
Source: Veterinary Research - Category: Veterinary Research Source Type: research