Signal intensity in the dentate nucleus after cumulative dose of Gd-EOB-DTPA: First results of a prospective longitudinal study.

Signal intensity in the dentate nucleus after cumulative dose of Gd-EOB-DTPA: First results of a prospective longitudinal study.
Clin Hemorheol Microcirc. 2020 Sep 08;:
Authors: Michalik K, Beyer L, Zeman F, Wendl C, Rennert J, Fellner C, Stroszczynski C, Wiggermann P
Abstract
Gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) is a hepatocyte-specific, linear ionic contrast agent for MRI. In comparison to other linear contrast agents Gd-EOB-DTPA is excreted equally through liver and kidneys. This prospective longitudinal study investigates the signal intensity (SI) in the dentate nucleus (DN) on unenhanced T1-weighted images after repetitive application of Gd-EOB-DTPA. 46 patients were included into the study and 107 MRI examinations were performed. Statistical analysis of 25 patients showed no significant correlation between cumulative dose of Gd-EOB-DTPA and SI change and between the DN/Pons ratiolast and the mean DN/Pons ratiofirst. Subgroup analysis however revealed a significant correlation for one out of two readers. Gd-EOB-DTPA deposition could not be proven in the framework of this study.
PMID: 32925023 [PubMed - as supplied by publisher]

Source: Clinical Hemorheology and Microcirculation - September 7, 2020 Category: Hematology Authors: Michalik K, Beyer L, Zeman F, Wendl C, Rennert J, Fellner C, Stroszczynski C, Wiggermann P Tags: Clin Hemorheol Microcirc Source Type: research