Past and current advances in Marburg virus disease: a review.

Past and current advances in Marburg virus disease: a review. Infez Med. 2020 Sep 01;28(3):332-345 Authors: Asad A, Aamir A, Qureshi NE, Bhimani S, Jatoi NN, Batra S, Ochani RK, Abbasi MK, Tariq MA, Diwan MN Abstract Marburg Virus (MARV), along with the Ebola virus, belongs to the family of Filovirus and is cause of a lethal and severely affecting hemorrhagic fever. The Marburgvirus genus includes two viruses: MARV and Ravn. MARV has been recognized as one of utmost importance by the World Health Organization (WHO). The case fatality rate of the virus ranges from 24.0 to 88.0% which demonstrates its lethal nature and the need for its widespread information. The first case of the Marburgvirus disease (MARD) was reported in 1967 when lab personnel working with African green monkeys got infected in Germany and Serbia simultaneously. Following the initial case, many more outbreaks occurred around the world such as Uganda, Angola, Congo, Kenya and even in the United States in 2008. It was soon found out that the MARV was a zoonotic virus and mainly contracted from animal-to-human contact and further transmitted via human-to-human contact. The Egyptian fruit bat (Rousettus aegyptiacus) is known to be one of the significant sources of the infection and tourists visiting caves inhabited by these bats or workers accessing mines, populated by the bats, are at an increased risk of contracting the illness. The incubation period ranges from 2-21 days and the clinical ...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research

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CONCLUSION: In this study, no influence of tear substitutes containing different viscosities of hyaluronic acid on the measurement results of optical coherence tomography could be determined. Therefore, 0.1%, 0.2% and 0.3% hyaluronic acid can be applied to the patient to improve the corneal surface before the examination with optical coherence tomography, without influencing the measurement results of optical coherence tomography. PMID: 33036058 [PubMed - as supplied by publisher]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Source: European Journal of Sport Science - Category: Sports Medicine Authors: Source Type: research
Conclusions: (1) Data at our center suggests at least a regional implementation gap in GBS screening and IAP. (2) The decline in the resistance rate ofE. coli for all antimicrobial substances might indicate that the reduction of prenatal antibiotics use is beneficial and that neonatal antibiotic stewardship programs should include pregnant women as well.What is Known:• GBS screening and intrapartum antibiotic prophylaxis led to a 32%-reduction in GBS disease in Germany with a 0.75 (92:122) ratio of early-onset disease to late-onset disease in 2009–2010.• Prenatal antibiotic use might increase the risk of E....
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
Abstract Trace metals concentrations of 25 elements were determined for 22 subcomponents of biodegradable and non-biodegradable waste samples representing the United States municipal solid waste (MSW) stream collected during three separate waste sorts. The subcomponent trace metal concentrations and estimated composition results were used to predict trace metal concentrations present in the overall MSW stream along with MSW compost and waste to energy (WTE) ash, which were compared to health-based standards (i.e., US EPA regional screening levels) and to values previously reported in the literature. These estimate...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Secretary Azar testified before Congress that “herd immunity is not the strategy of the U.S. government.” Yet, frequently the Trump Administration’s rhetoric tells a different story. The Administration’s recent actions on the ground belie its claims of not advancing a herd immunity policy.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Tags: Healthcare /healthcare Innovation /innovation business pharma & Source Type: news
Publication date: Available online 11 December 2018Source: Antiviral ResearchAuthor(s): Christopher F. Basler, Nevan J. Krogan, Daisy W. Leung, Gaya K. AmarasingheAbstractFiloviruses, which include Ebola virus and Marburg virus, are negative-sense RNA viruses associated with sporadic outbreaks of severe viral hemorrhagic fever characterized by uncontrolled virus replication. The extreme virulence and emerging nature of these zoonotic pathogens make them a significant threat to human health. Replication of the filovirus genome and production of viral RNAs requires the function of a complex of four viral proteins, the nucleo...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Filoviruses, which include Ebola virus and Marburg virus, are negative-sense RNA viruses associated with sporadic outbreaks of severe viral hemorrhagic fever characterized by uncontrolled virus replication. The extreme virulence and emerging nature of these zoonotic pathogens make them a significant threat to human health. Replication of the filovirus genome and production of viral RNAs requires the function of a complex of four viral proteins, the nucleoprotein (NP), viral protein 35 (VP35), viral protein 30 (VP30) and large protein (L). The latter performs the enzymatic activities required for productio...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Conclusion Ecological niche modeling techniques have been widely used in predicting where disease outbreaks are likely to occur, more specifically where species have suitable living conditions depending on their environmental factors. The MaxEnt modeling algorithm uses presence only occurrence data and has been useful to estimate species’ niche in environmental space where absence records for a species are not available as it is the case with filoviruses. Given the public and global importance of filoviruses, developing models that predict where they are likely to occur is very important, and efforts in this directi...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
Abstract: The viruses that cause the Viral Haemorrhagic Fevers (VHFs) are largely zoonotic. Consequently, the endemic areas for the various VHFs are limited to the distribution of their mammalian reservoirs and/or arthropod vectors. Ecological changes, agricultural and cultural practices, population migration and land use may have an affect on the emergence and occurrence of the VHfs . Consequently a ‘One Health’ approach is important in surveillance, response and control of outbreaks of Filoviruses (Marburg and Ebola), the Bunyaviridiae (Crimean Congo haemorraghic fever and Rift Valley fever) and Flaviviruses ...
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Type: Invited Presentation Source Type: research
The filoviruses, Ebola virus and Marburg virus, are zoonotic pathogens that cause severe hemorrhagic fever in humans and nonhuman primates (NHPs), with case-fatality rates ranging from 23% to 90%. The current outbreak of Ebola virus infection in West Africa, with>26 000 cases, demonstrates the long-underestimated public health danger that filoviruses pose as natural human pathogens. Currently, there are no vaccines or treatments licensed for human use. Licensure of any medical countermeasure may require demonstration of efficacy in the gold standard cynomolgus or rhesus macaque models of filovirus infection. Substantial...
Source: The Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: PERSPECTIVE Source Type: research
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