Developing Meaningful Endpoints for Pain Clinical Trials (Day 2)

More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. In recent decades, there has been an overreliance on the prescription of opioids for chronic pain, contributing to a significant and alarming epidemic of opioid overdose deaths and addiction. Innovative scientific solutions to develop non-opioid, non-addictive alternative treatment options are thus urgently needed. One of the goals of the Helping to End Addiction Long-term (HEAL) Initiative is to accelerate the discovery and preclinical development of new medications and devices to treat pain. Two recent NINDS workshops focused on (1) identifying endpoints in pre-clinical pain models and (2) discovering biomarkers to enhance pain therapy development. A logical next step is to identify the scientific gaps and development challenges in moving candidate therapeutics through proof-of-concept studies, early phase clinical trials and to later phases of development including regulatory approval. One major challenge facing the development of non-opioid alternative pain medications in each pain condition is the heterogeneity in patient populations combined with high variability in individual responses to any given intervention. This is further compounded by the diversity of specific disorders associated with pain. Consequently, it is often difficult to define reliable endpoints, both within specific pain conditions and across pain conditions...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video

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More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. In recent decades, there has been an overreliance on the prescription of opioids for chronic pain, contributing to a significant and alarming epidemic of opioid overdose deaths and addiction. Innovative scientific solutions to develop non-opioid, non-addictive alternative treatment options are thus urgently needed. One of the goals of the Helping to End Addiction Long-term (HEAL) Initiative is to accelerate the discovery and preclinical development of new medications and devices t...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
AbstractOpioid-related death and overdose have now reached epidemic proportions. In response to this public health crisis, the National Institutes of Health (NIH) launched the Helping to End Addiction Long-term InitiativeSM, or NIH HEAL InitiativeSM, an aggressive, trans-agency effort to speed scientific solutions to stem the national opioid public health crisis. Herein, we describe two NIH HEAL Initiative programs to accelerate development of non-opioid, non-addictive pain treatments: The Preclinical Screening Platform for Pain (PSPP) and Early Phase Pain Investigation Clinical Network (EPPIC-Net). These resources are pro...
Source: Neurotherapeutics - Category: Neurology Source Type: research
Abstract Chronic pain is considered a public health crisis due to its high prevalence, impact, costs, and disparities in pain prevalence and treatment. In parallel, drug overdose, particularly due to opioids, has become an epidemic in the United States, prompting a public health crisis concerning harms associated with both prescribed opioid therapy for chronic pain and illicit opioid use. The purpose of this special issue is to highlight state-of-the-art psychological research that addresses the combined issues of chronic pain and harms associated with opioids. Articles included in this special issue focus on 2 re...
Source: The American Psychologist - Category: Psychiatry & Psychology Authors: Tags: Am Psychol Source Type: research
We describe the historical use of opioids and the scope of the current opioid crisis, review the differences between dependence and addiction, and the private and public sectors response to pain management and highlight the issue of adolescent vulnerability. We conclude with a proposal for future directions that address both public and patient health needs.
Source: Current Opinion in Anaesthesiology - Category: Anesthesiology Tags: PEDIATRIC ANESTHESIA: Edited by Jorge A. Gálvez Source Type: research
Background Opioids can induce significant respiratory depression when administered as analgesics for the treatment of acute, postoperative, and chronic pain. There are currently no pharmacologic means of reversing opioid-induced respiratory depression without interfering with analgesia. Further, there is a growing epidemic of opioid overdose that could benefit from therapeutic advancements. The aim of this study was to test the ability of two partial agonists of α4β2 nicotinic acetylcholine receptors, varenicline (used clinically for smoking cessation) and ABT 594 (tebanicline, developed as an analgesic), to red...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. In recent decades, there has been an overreliance on the prescription of opioids for chronic pain, contributing to a significant and alarming epidemic of opioid overdose deaths and addiction. Innovative scientific solutions to develop non-opioid, non-addictive alternative treatment options are thus urgently needed. One of the goals of the Helping to End Addiction Long-term (HEAL) Initiative is to accelerate the discovery and preclinical development of new medications and devices to...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. In recent decades, there has been an overreliance on the prescription of opioids for chronic pain, contributing to a significant and alarming epidemic of opioid overdose deaths and addiction. Innovative scientific solutions to develop non-opioid, non-addictive alternative treatment options are thus urgently needed. One of the goals of the Helping to End Addiction Long-term (HEAL) Initiative is to accelerate the discovery and preclinical development of new medications and devices to...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
According to a new report by Orange County, California’s health care agency, the overdose deaths in Orange County have greatly surpassed that of Los Angeles, Riverside, San Bernardino, San Diego, Ventura, and Santa Barbara counties and, most shockingly, all of California as a whole. The opioid crisis in Orange County has grown so much that a high concentration of treatment centers has popped up in the area hoping to combat this issue, but it doesn’t seem to be enough. In addition, the report details that the majority of state-licensed treatment centers and unregulated sober living homes are located along the c...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Detox Resources for Alcohol and Drugs/Opiates opiate abuse opiate addiction opioid opioid crisis opioids orange county Source Type: blogs
Opioids are so highly addictive that they have created a dangerous and deadly epidemic in the United States. In fact, the National Institute on Drug Abuse reports that more than 2 million Americans abuse opioids and that more than 90 Americans die on average by opioid overdose every day. Individuals can become addicted to opioids so quickly that it can be difficult to notice when the line has been crossed over to opioid abuse. If you or your loved one is taking opioids, whether legal or illegal, make note of these signs and symptoms of opioid abuse and how to get help. How Does Opioid Abuse Begin? Opioids work by binding ...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Recovery Addiction to Pharmaceuticals Detox Resources for Alcohol and Drugs/Opiates abuse heroin heroin addiction heroin users opiate abuse opioid opioid crisis opioids prescription drug abuse prescription drug addiction Source Type: blogs
Conclusion: Safer prescribing policies may take multiple years to fully implement and need to be employed across the jurisdiction to minimize doctor-shopping and adverse effects on patients with chronic pain. Approaching pain management through the social-ecological model can address potential root causes of addiction and establish a framework for doctors to provide compassionate care, community leadership, and advocacy for these patients. PMID: 31790125 [PubMed - in process]
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
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