Ubc9 Attenuates Myocardial Ischemic Injury Through Accelerating Autophagic Flux

ConclusionsWe uncovered a novel role of Ubc9 in protecting cardiomyocytes from ischemic stress via Ubc9-induced SUMOylation, leading to increased PI3K-III complex assembly and autophagy-positioning. These findings may indicate a potential therapeutic target, Ubc9, for treatment of myocardial ischemia.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research