Relation of High-Sensitivity Cardiac Troponin I Elevation with Exercise to Major Adverse Cardiovascular Events in Patients with Coronary Artery Disease

High sensitive cardiac troponin I (hs-cTnI) increases with inducible myocardial ischemia in patients with coronary artery disease (CAD). We aimed to assess if the change in hs-cTnI levels with exercise stress testing is associated with major adverse cardiac events (MACE). A cohort of 365 (age 62 ± 9 years, 77% men) patients with stable CAD underwent 99mTc sestamibi myocardial perfusion imaging with treadmill testing. Plasma hs-cTnI level was measured at rest and at 45 min after stress. Multivariable Fine& Gray's sub-distribution hazards models (sHR) were used to determine the association between the change in hs-cTnI and MACE, a composite endpoint of cardiovascular death, myocardial infarction, and unstable angina requiring revascularization.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research