Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development

Capsule SummaryWe identify an NLRP3 gain-of-function variant that is activated in the colon via post-translational mechanism. It will facilitate diagnosis and precision treatment for patients with NLRP3-associated VEOIBD.

Source: Journal of Allergy and Clinical Immunology - September 13, 2020 Category: Allergy & Immunology Authors: Lingli Zhou, Tao Liu, Bing Huang, Man Luo, Zhanghua Chen, Zhiyao Zhao, Jun Wang, Daniel Leung, Xingtian Yang, Koon Wing Chan, Yukun Liu, Liya Xiong, Peiyu Chen, Hongli Wang, Liping Ye, Hanquan Liang, Seth L. Masters, Andrew M. Lew, Sitang Gong, Fan Bai, J Source Type: research