The Role of Autophagy in Targeted Therapy for Acute Myeloid Leukemia.

The Role of Autophagy in Targeted Therapy for Acute Myeloid Leukemia.
Autophagy. 2020 Sep 11;:
Authors: Du W, Xu A, Huang Y, Cao J, Zhu H, Yang B, Shao X, He Q, Ying M
Abstract
Although molecular targeted therapies have recently displayed therapeutic effects in acute myeloid leukemia (AML), limited response and acquired resistance remain common problems. Numerous studies have associated autophagy, an essential degradation process involved in the cellular response to stress, with the development and therapeutic response of cancers including AML. Thus, we review studies on the role of autophagy in AML development and summarize the linkage between autophagy and several recurrent genetic abnormalities in AML, highlighting the potential of capitalizing on autophagy modulation in targeted therapy for AML.
PMID: 32917124 [PubMed - as supplied by publisher]

Source: Autophagy - September 10, 2020 Category: Cytology Authors: Du W, Xu A, Huang Y, Cao J, Zhu H, Yang B, Shao X, He Q, Ying M Tags: Autophagy Source Type: research