Cross-Species Physiological Assessment of Brain Estrogen Receptor Expression Using 18 F-FES and 18 F-4FMFES PET Imaging

Conclusion4FMFES allowed visualization of ER expression in the pituitary in humans and two different rodent species with better contrast than FES. Improvement in clinical spatial resolution might allow visualization and analysis of other ER-rich brain areas in humans. Further work is now possible to link 4FMFES pituitary uptake to cognitive functions.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research