IJERPH, Vol. 17, Pages 6688: Neurological Complications of COVID-19 and Possible Neuroinvasion Pathways: A Systematic Review

IJERPH, Vol. 17, Pages 6688: Neurological Complications of COVID-19 and Possible Neuroinvasion Pathways: A Systematic Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17186688 Authors: Graziella Orrù Ciro Conversano Eleonora Malloggi Francesca Francesconi Rebecca Ciacchini Angelo Gemignani The Coronavirus Disease 2019 (COVID-19) outbreak has shocked the whole world with its unexpected rapid spread. The virus responsible for the disease, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), enters host cells by means of the envelope spike protein, which binds to angiotensin-converting enzyme 2 receptors. These receptors are highly expressed in heart, lungs, respiratory tract epithelium, endothelial cells and brain. Since an increasing body of significant evidence is highlighting a possible neuroinvasion related to SARS-CoV-2, a state of the art on the neurological complications is needed. To identify suitable publications, our systematic review was carried out by searching relevant studies on PubMed and Scopus databases. We included studies investigating neurologic manifestations of SARS-CoV-2 in patients over 18. According to the analyzed studies, the most frequent disorders affecting central nervous system (CNS) seem to be the following: olfactory and taste disorders, ischemic/hemorrhagic stroke, meningoencephalitis and encephalopathy, including acute necrotizing encephalopathy, a rare type of encephal...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research