Positive association between PTN polymorphisms and schizophrenia in Northeast Chinese Han population

In this study, we aimed to investigate the association between PTN polymorphisms and schizophrenia in an independent case-control sample-set including 738 schizophrenia patients and 1085 healthy controls. Of the 13 selected single nucleotide polymorphisms (SNPs), five showed significant differences in allele or/and genotype frequencies between patients and controls: rs3959914 (genotype: χ2 = 11.5217, P = 0.0032); rs11765480 (genotype: χ2 = 10.6620, P = 0.0049); rs1473355 (genotype: χ2 = 8.3902, P = 0.0151); rs322246 (allele: χ2 = 5.5954, P = 0.0180); rs322240 (genotype: χ2 = 8.8429, P = 0.0121; allele: χ2 = 8.7802, P = 0.0031). The haplotype analysis of the selected SNPs showed different haplotype frequencies for one block (rs322240, rs322246) between cases and controls (global: χ2 = 9.0290, P = 0.0110; A-G: χ2 = 8.985, P = 0.0027; C-A: χ2 = 5.814, P = 0.0159). Our present results indicate PTN as a susceptibility gene for schizophrenia.
Source: Psychiatric Genetics - Category: Genetics & Stem Cells Tags: Original Articles Source Type: research