Proximal Resistance Training for People With Multiple Sclerosis

Condition:   Multiple Sclerosis Intervention:   Other: Proximal Resistance Training Sponsors:   University of Colorado, Denver;   National Institute of Neurological Disorders and Stroke (NINDS);   National Institutes of Health (NIH);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

Related Links:

Recent advances in artificial intelligence (AI) and deep learning (DL) hold promise to augment neuroimaging diagnosis for patients with brain tumors and stroke. Here, the authors review the diverse landscape of emerging neuroimaging applications of AI, including workflow optimization, lesion segmentation, and precision education. Given the many modalities used in diagnosing neurologic diseases, AI may be deployed to integrate across modalities (MR imaging, computed tomography, PET, electroencephalography, clinical and laboratory findings), facilitate crosstalk among specialists, and potentially improve diagnosis in patient...
Source: Neuroimaging Clinics - Category: Radiology Authors: Source Type: research
The current COVID-19 pandemic presents unprecedented new challenges to public health and medical care delivery. To control viral transmission, social distancing measures have been implemented all over the world, interrupting the access to routine medical care for many individuals with neurological diseases. Cognitive disorders are common in many neurological conditions, e.g., stroke, traumatic brain injury, Alzheimer's disease, and other types of dementia, Parkinson's disease and parkinsonian syndromes, and multiple sclerosis, and should be addressed by cognitive rehabilitation interventions. To be effective, cognitive reh...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Condition:   Multiple Sclerosis Intervention:   Other: Proximal Resistance Training Sponsors:   University of Colorado, Denver;   National Institute of Neurological Disorders and Stroke (NINDS);   National Institutes of Health (NIH);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: Since CADASIL is a rare disease, it is imperative to raise awareness of its unique clinical condition as well as variation in its clinical presentations. It is crucial that the overlapping symptoms between MS and CADASIL be thoroughly examined to avoid misdiagnosis and treatment complications. The involvement of autoimmune mechanisms in CADASIL and the role of NOTCH3 gene mutations in provoking an autoimmune process should be further investigated.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionsTLNS is a promising treatment modality for various chronic neurological conditions that are often refractory to conventional therapy. However, TLNS technology remains largely investigational as high ‐quality RCTs are still required to elucidate efficacy, optimal dosages, necessary treatment durations, and treatment durability. Further research to develop an appropriate control group is needed for scientifically valid comparisons of TLNS.
Source: Neuromodulation: Technology at the Neural Interface - Category: Biotechnology Authors: Tags: Review Article Source Type: research
AbstractNeuroinflammatory and neurodegenerative diseases are characterised by the recruitment of circulating blood ‐borne innate and adaptive immune cells into the central nervous system (CNS). These leukocytes sustain the detrimental response in the CNS by releasing pro‐inflammatory mediators that induce activation of local glial cells, blood‐brain barrier (BBB) dysfunction and neural cell death. However, infiltrating peripheral immune cells could also dampen CNS inflammation and support tissue repair. Recent advances in the field of immunometabolism demonstrate the importance of metabolic reprogramming for the acti...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: REVIEW Source Type: research
Before we get on with this week’s Psychology Around the Net, I need to let you know that this will be the last one. Healthline has purchased Psych Central and content production stops August 31, 2020. Dr. John Grohol, Psych Central’s founder and our fearless leader, recently shared his reflections and gratitude. Additionally, many of our talented and knowledgeable contributers have shared goodbye posts, and invitations to follow their new blogs. Now, let’s see what’s new in the world of mental health this week! The Psychology Behind Why Some College Students Break COVID-19 Rules: According to deve...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Psychology Around the Net Burnout College Students coronavirus COVID-19 Fatigue Happiness Life Satisfaction Mood pandemic Source Type: blogs
Abstract Central nervous system (CNS) injuries, such as traumatic brain injury (TBI), subarachnoid hemorrhage (SAH) and intracerebral hemorrhage (ICH), are important causes of disability and death worldwide. FTY720, a structural sphingosine analog and sphingosine-1-phosphate receptor (S1PR) modulator, is currently used in the treatment of relapsing-remitting multiple sclerosis (RRMS). However, recent in vivo and in vitro studies suggest that FTY720 plays a key role in many neurological diseases, especially in CNS injuries. In addition, FTY720 is under clinical trial for the treatment of acute stroke and ICH. FTY72...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
CONCLUSIONS AND RELEVANCE: HMD-VR is an emerging technology with many uses in adult physical rehabilitation. Higher quality clinical implementation studies are needed to examine effects on patient outcomes. WHAT THIS ARTICLE ADDS: We review existing research on how immersive virtual reality (e.g., using head-mounted displays) has been used for different clinical populations in adult physical rehabilitation and highlight emerging opportunities in this field for occupational therapists. PMID: 32804624 [PubMed - as supplied by publisher]
Source: The American Journal of Occupational Therapy - Category: Occupational Health Authors: Tags: Am J Occup Ther Source Type: research
More News: Brain | Child Development | Children | Multiple Sclerosis | Neurology | Research | Stroke | Training | Universities & Medical Training