Fragility of clinical trials across research fields: A synthesis of methodological reviews

Randomized controlled trials (RCTs) are often used to inform clinical practice and it is desirable that their results be robust. A fragility index (FI), defined as the smallest number of participants in whom an outcome change from non-event to event would turn a statistically significant result to a non-significant result, can be computed to measure robustness. We sought to determine the distribution of fragility indices across various research areas and summarized the factors associated with fragility.

Source: Contemporary Clinical Trials - September 13, 2020 Category: Radiology Authors: Matthew Holek, Faris Bdair, Mohammed Khan, Michael Walsh, P.J. Devereaux, Stephen D. Walter, Lehana Thabane, Lawrence Mbuagbaw Source Type: research