Molecular Mechanism of Helicobacter pylori -Induced Gastric Cancer

ConclusionThe bacterium has various virulence factors, including cytotoxin- associated gene A, vacuolating cytotoxin A, and the different outer membrane proteins that cause cancer by different mechanisms. These virulence factors activate cell signaling pathways such as PI3-kinase/Akt, JAK/STAT and Ras, Raf, and ERK signaling that control cell proliferation. Uncontrolled proliferation can lead to cancer.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research