Longitudinal Relationships of Cytokines, Depression and Anhedonia in Depressed Adolescents.

CONCLUSIONS: Among adolescents receiving standard-of-care community treatment for depression, higher levels of TNFα predicted greater depressive symptoms at 4-month follow-up, suggesting this cytokine may be used to help identify patients in need of more intensive treatment. Elevated TNFα levels were also associated with concurrent and future anhedonia symptoms, suggesting a specific mechanism in which TNFα affects depression trajectories. Future studies should examine the relationships between cytokine levels and depression/anhedonia symptoms at multiple timepoints in larger cohorts of depressed adolescents.
PMID: 32919038 [PubMed - as supplied by publisher]

Source: Brain, Behavior, and Immunity - September 8, 2020 Category: Neurology Authors: Rengasamy M, Marsland A, McClain L, Kovats T, Walko T, Pan L, Price RB Tags: Brain Behav Immun Source Type: research