Effect Sizes of Deletions and Duplications on Autism Risk Across the Genome.

CONCLUSIONS: Autism risk conferred by duplications is less influenced by IQ compared with deletions. The model applied in this study, trained on CNVs encompassing >4,500 genes, suggests highly polygenic properties of gene dosage with respect to autism risk and IQ loss. These models will help to interpret CNVs identified in the clinic. PMID: 32911998 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32911998?dopt=Abstract

Source: The American Journal of Psychiatry - September 10, 2020 Category: Psychiatry Authors: Douard E, Zeribi A, Schramm C, Tamer P, Loum MA, Nowak S, Saci Z, Lord MP, Rodríguez-Herreros B, Jean-Louis M, Moreau C, Loth E, Schumann G, Pausova Z, Elsabbagh M, Almasy L, Glahn DC, Bourgeron T, Labbe A, Paus T, Mottron L, Greenwood CMT, Huguet G, Jac Tags: Am J Psychiatry Source Type: research