Should mother's milk be produced in the lab?

Human milk grown from mammary cells could liberate breastfeeding women – but it’s a controversial sellOne of the saddest things about being diagnosed with breast cancer a few years ago (it was fortunately treatable) was having to stop breastfeeding my 10-month-old baby. Unceremoniously she was shunted on to an early diet of pure solid food, which I reasoned was probably just as nutritious as infant formula and the best solution in the absence of donor milk from a breast-milk bank, which is reserved for premature and ill babies, and dispensed by prescription.Baby Agnes thrived, but what if there were another option? What if we could make human breast milk in the lab? Enter startupsBiomilq andTurtleTree Labs, founded in 2019 and based in the US (North Carolina) and Singapore respectively. The companies believe they can provide a more nutritious alternative to infant formula by inducing human mammary cells in a bioreactor to lactate, then harvesting the product. “The end goal is a product that is as close to breast milk as we can produce,” says Michelle Egger, Biomilq’s co-founder and CEO.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Breastfeeding Parents and parenting Family Breast cancer Health & wellbeing Society Life and style Source Type: news

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CONCLUSION: The study identified both a high prevalence of xerostomia regardless of the chemotherapy used and the need to create protocols to improve the quality of life of these patients. PMID: 32965427 [PubMed - in process]
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
Condition:   Musculoskeletal Pain Intervention:   Drug: Etoricoxib Sponsor:   Guangdong Provincial People's Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Piña-Sánchez P, Valdez-Salazar HA, Ruiz-Tachiquín ME Abstract Breast cancer (BC) is the most common type of cancer in women worldwide, and despite advances in treatments, its incidence and mortality are increasing. Therefore, it is necessary to develop new, non-invasive tests that provide more accurate diagnosis and prognosis in a timely manner. A promising approach is measuring the presence of biomarkers to detect tumors at various stages and determine their specific characteristics, thus allowing for more personalized treatment. MicroRNAs (miRNAs) serve a role in gene expression, pri...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Role of TG2 and TGF-β1 in the pathogenesis of human breast cancer. Oncol Lett. 2020 Nov;20(5):221 Authors: Gao HC, Huang YZ, Liu YQ, Chen Y, Wang ZH, Yin GH Abstract The present study analyzed the role of transforming growth factor-β1 (TGF-β1) and tissue transglutaminase (TG2) in breast cancer, as well as their protein levels in MCF-7 cells treated with cisplatin. In addition, the present study investigated the effects of TG2 and TGF-β1 in MCF-7 cells following TGF-β1 and TG2 inhibition or TGF-β1 induction. The protein levels of TG2 and TGF-β1 in breast cancer tissues...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Wu M, Zhao H Abstract Breast cancer (BC) remains the most common cancer in females. Therefore, the present study aimed to identify key genes involved in the carcinogenesis of BC and to explore their prognostic values by integrating bioinformatics tools. The gene expression profiles of 46 ductal carcinoma in situ (DCIS) and three normal breast tissues from the GSE59248 dataset were downloaded. Differentially expressed genes (DEGs) were subsequently identified using the online tool GEO2R and a functional enrichment analysis was performed. In addition, a protein-protein interaction (PPI) network was construct...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Cao X, Zhou Y, Mao F, Lin Y, Sun Q Abstract Previous studies have demonstrated that the combination of high preoperative fibrinogen levels and high neutrophil-to-lymphocyte ratio (NLR) is associated with poor outcomes in various types of cancer. The present study assessed the prognostic value of a scoring system based on the combination of fibrinogen concentration and neutrophil-to-lymphocyte ratio (F-NLR) in untreated patients with resectable breast cancer (BC). The present study retrospectively analyzed 906 patients who received surgery for resectable BC. Univariate and multivariate analyses were perform...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Watanabe M, Shibata M, Inaishi T, Ichikawa T, Soeda I, Miyajima N, Takano Y, Takeuchi D, Tsunoda N, Kanda M, Kikumori T, Kodera Y, Nagino M Abstract Breast cancer (BC) is the most common malignant tumor in females. Development of novel biomarkers or therapeutic targets may contribute toward the improvement of a patient's prognosis. Marginal zone B and B1 cell-specific protein (MZB1) is an unfolded protein response-related chaperone and mainly exists in the endoplasmic reticulum of B lymphocytes, although little is known regarding its role in BC cells. The present study aimed to investigate the significance...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Source: Journal of Computational and Theoretical Nanoscience - Category: Nanotechnology Authors: Tags: research-article Source Type: research
Abstract BACKGROUND: Massage therapy's ability to mitigate breast imaging associated anxiety has not been previously studied. Anxiety is, however, often cited as a harm of screening mammography with few options offered to diminish anxiety other than not screening. Reducing anxiety may improve compliance, and reduce breast cancer mortality and morbidity. A complimentary massage therapy program evaluated patient acceptance, anxiety perception and perceived value of massage. METHODS: Over 10 weeks, verbal agreement was obtained from 113 breast imaging patients who desired a hand or shoulder/neck massage. Li...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Clin Imaging Source Type: research
Abstract Large amounts of misinformation denigrating the benefits of breast cancer screening have been published over the past 50 years and continue to be published. Each effort to reduce breast cancer screening has been refuted, scientifically, but the efforts continue. The motivation has been unclear until the recent guidelines issued by the American Society of Breast Surgeons who support annual screening starting at the age of 40 contrasted with the American College of Physicians who advocated delaying screening until the age of 50 and then biennially. An analysis of the facts can only lead to the conclusi...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Clin Imaging Source Type: research
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