Anticandidal formyl phloroglucinol meroterpenoids: Biomimetic synthesis and in vitro evaluation.
Anticandidal formyl phloroglucinol meroterpenoids: Biomimetic synthesis and in vitro evaluation.
Bioorg Chem. 2020 Sep 01;104:104248
Authors: Zhong LF, Shang ZC, Sun FJ, Zhu PH, Yin Y, Kong LY, Yang MH
Abstract
Inspired by the diversity-oriented synthesis, some novel formyl phloroglucinol meroterpenoids were synthesized via biomimetic synthesis using essential oils. Eight of them were demonstrated with good in vitro fungicidal activity against Candida albicans and C. glabrata. Compound c2 showed the best anticandidal ability that was powerfully comparable to fluconazole when testing against several strains in vitro. The antibiofilm activity was also found for the c2 treating group which was evidenced to block the hyphal elongation and filamentation of C. albicans. Therefore, compound c2 is a promising candidate for further antifungal-based structure modification.
PMID: 32916392 [PubMed - as supplied by publisher]
Source: Bioorganic Chemistry - Category: Chemistry Authors: Zhong LF, Shang ZC, Sun FJ, Zhu PH, Yin Y, Kong LY, Yang MH Tags: Bioorg Chem Source Type: research