In situ hybridisation in tissue sections

The identification of recurrent tumour-specific chromosomal abnormalities, including rearrangements and copy number changes, has shown increasingly important diagnostic, therapeutic and prognostic implications. In surgical pathology, fluorescence in situ hybridization (FISH) is a quick and reliable method for the detection of many genetics aberrations, and can be applied to a variety of specimens including formalin-fixed paraffin-embedded (FFPE) tissues; as such, it has been successfully incorporated into diagnostic practice for lymphomas, mesenchymal and other solid tumours.

Source: Diagnostic Histopathology - September 11, 2020 Category: Pathology Authors: Laura Chiecchio Tags: Mini-symposium: Techniques in histopathology Source Type: research