Effectiveness of clozapine on quality of life and functioning in patients with treatment-resistant schizophrenia.

CONCLUSIONS: Treatment with clozapine leads to improvement in core symptoms of schizophrenia and is also associated with significant improvement in the quality of life, functioning, and disability. PMID: 32915089 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research

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AbstractEmergency psychiatry has the main role of resolving suicidal behavior and aggression. These severe psychiatric symptoms can be found in many psychiatric disorders such as schizophrenia, bipolar disorder, major depression, personality disorders, cognitive disorders, intellectual disability and substance abuse. Although indications for the use of antipsychotics are limited to a specific group of diseases, they are frequently used as rescue medication in high-risk or nonresponsive cases. Clozapine, the gold standard for TRS (treatment resistant schizophrenia) is effective in controlling aggression. The aim of the rese...
Source: Psychiatric Quarterly - Category: Psychiatry Source Type: research
CONCLUSIONS: These findings suggest that motivational deficits could play a central role in disability caused by OCD. Similar to other mental disorders, various psychological factors, including depression, defeatist beliefs, and dysexecutive functioning, are involved in apathetic manifestations. However, the fact that depression is the variable most associated with apathy indicates that apathetic symptoms in patients with OCD must be considered mainly as secondary rather than primary symptoms. PMID: 31266408 [PubMed - as supplied by publisher]
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
Hui Xu1,2,3, Chenguang Guo1, Haining Li1, Lin Gao2, Ming Zhang1* and Yuan Wang1* 1Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China 2Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an, China 3Faculty of Dentistry, University of Toronto, Toronto, ON, Canada Background and Purpose: Hemifacial spasm (HFS) is a rare neuromuscular disorder characterized by unilateral, involuntary, and paroxysmal contractions of orofacial muscles. To eluci...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In this study, we investigated the effects of two novel smartphone interventions on cognitive flexibility and OCD symptoms in healthy individuals with OCD-like contamination fears. In the first intervention, participants watched a brief video recording of themselves engaging in handwashing on a smartphone, four times a day, for a total of one week (N=?31). The second intervention was similar except that participants watched themselves repeatedly touching a disgust-inducing object (N=?31). In a third (control) “intervention”, participants watched themselves performing sequential hand movements (N=?31). As hypoth...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Technology app Brain-Training brain-training-app cognitive-flexibility handwashing obsessive-compulsive disorder OCD smartphone Source Type: blogs
Conclusion We believe our diagnosis of schizo-obsessive disorder in the described patient is appropriate due to his symptoms of schizophrenia and OCD. The OCS at first seemed to have retarded the psychotic manifestation; however, the negative and cognitive symptoms of schizophrenia associated with OCS were prominent, and we believe this greatly contributed to the poor prognosis of our patient. The improvement of his OCS occurred with the emergence of an over-valued idea, corroborating the existence of a schizo-obsessive spectrum modulated by the presence and extent of phenomenological features related to insight. Therefore...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report Current Issue Neurodegenerative Disease Schizophrenia comorbidity insight obsessive compulsive disorder Source Type: research
Conclusions: The relatively low level of inflammatory saliva cytokines observed in the current study (negative z scores versus normative data with medium effect sizes) indicates that evaluation of blood inflammatory levels in trichotillomania versus matched controls would be valuable in future work. If a hypoinflammatory state is confirmed ­using blood samples, this would differentiate trichotillomania from other mental disorders (such as OCD, schizophrenia, and depression), which have typically been linked with high inflammatory measures in the literature, at least in some cases.Neuropsychobiology
Source: Neuropsychobiology - Category: Psychiatry & Psychology Source Type: research
More than one in four patients with schizophrenia experience comorbid symptoms of obsessive-compulsive disorder (OCD), according to astudy published in thePsychiatry Research. The findings highlight the importance of regularly evaluating OCD symptoms in this patient population, which could inform treatment strategies. For the current study, Sandeep Grover, M.D., a professor of psychiatry at the Postgraduate Institute of Medical Education and Research in India and colleagues recruited 181 adults with schizophrenia. The patients were evaluated using several screening tools, including the Yale-Brown Obsessive-Compulsive ...
Source: Psychiatr News - Category: Psychiatry Tags: depression obsessive-compulsive disorder remission schizophenia suicidal ideation Source Type: research
I Am... Struggling with Anxiety: Create your own profile at Anxiety Social Net (anxietysocialnet.com) to connect with people dealing with everything from social anxiety to agoraphobia. Prefer to meet in person? Find a state-by-state list of support groups at the Anxiety and Depression Association of America’s website (adaa.org). Struggling with Depression or Bipolar Disorder: Locate an in-person or online group at the Depression and Bipolar Support Alliance site (dbsalliance.org). Struggling with Postpartum Depression: The Postpartum Progress site (postpartumprogress.com) lists support groups in nearly every state as...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
The aim of this study was to evaluate the prevalence of comorbid obsessive compulsive symptoms and its impact on outcome among patients with schizophrenia. 181 patients with schizophrenia were evaluated on Yale-Brown Obsessive –Compulsive Symptom Checklist, Yale-Brown Obsessive–Compulsive Scale, Calgary Depression Scale for Schizophrenia, Positive and Negative Symptom Scale, Social Occupational Functioning Scale, Global Assessment of Functioning Scale and Indian Disability Evaluation and Assessment Scale.
Source: Psychiatry Research - Category: Psychiatry Authors: Source Type: research
CONCLUSIONS: Anxiety symptoms are common in people with psychotic disorders. Appropriate screening and treatment should be a clinical priority. PMID: 27440210 [PubMed - in process]
Source: Clinical Schizophrenia and Related Psychoses - Category: Psychiatry Tags: Clin Schizophr Relat Psychoses Source Type: research
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