Multiplex immunofluorescence in formalin-fixed paraffin-embedded tumor tissue to identify single cell-level PI3K pathway activation.

CONCLUSION: Our novel pathway-focused approach to quantifying single cell-level immunofluorescence in FFPE tissue identifies prostate tumors with PI3K pathway activation that are more aggressive and may respond to pathway inhibitors.
PMID: 32913135 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - September 9, 2020 Category: Cancer & Oncology Authors: Stopsack KH, Huang Y, Tyekucheva S, Gerke TA, Bango C, Elfandy H, Bowden M, Penney KL, Roberts TM, Parmigiani G, Kantoff PW, Mucci LA, Loda M Tags: Clin Cancer Res Source Type: research