Lab-on-paper strip: Small, inexpensive platform for diagnosing tropical fevers

(GIST (Gwangju Institute of Science and Technology)) Dengue, zika, and chikungunya viruses are transmitted by mosquitoes and cause tropical fevers with similar symptoms, making accurate diagnosis complicated. Now, researchers from Gwangju Institute of Science and Technology in Korea have developed a simple and low-cost diagnostic platform--a lab-on-paper strip--that can readily detect the specific RNA of these viruses from a small blood sample.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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by Pie M üller, Lukas Engeler, Laura Vavassori, Tobias Suter, Valeria Guidi, Martin Gschwind, Mauro Tonolla, Eleonora Flacio Over the past three decades, Europe has witnessed an increased spread of invasive aedine mosquito species, most notablyAedes albopictus, a key vector of chikungunya, dengue and Zika virus. While its distribution in southern Europe is well documented, its dispersal modes across the Alps remain poorly investigated, preventing a projection of future scenarios beyond its current range in order to target mosquito control. To monitor the presence and frequency of invasiveAedes mosquitoes across and b...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Conclusions: From all the circulating mediators measured, we detected differences of IL-10, TNF- α, and CCL2/MCP-1 between arbovirus groups. We hypothesize that CXC10/IP-10, CCL2/MCP-1, and MIF in the CHIKV-infected group could regulate the CHIKV viral load, while CXC10/IP-10, CCL2/MCP-1, and TNF-α in DENV/ZIKV, and CHIKV/ZIKV groups, could regulate ZIKV viral load.Intervirology
Source: Intervirology - Category: Virology Source Type: research
Aedes spp. are responsible for the transmission of many arboviruses, which contribute to rising human morbidity and mortality worldwide. The Aedes aegypti mosquito is a main vector for chikungunya, dengue and yel...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
es SG Abstract Zika and Dengue viruses present considerable immunological cross-reactivity, resulting in a troublesome serodiagnosis due to occurrence of false positive results. Due to Brazil's wide variety of circulating flaviviruses we aimed to access the use of in house serological tests adapted by National Reference Laboratory for Arboviruses in Brazil and evaluate commercial tests available. We evaluated in house IgM ELISAs for the individual detection of anti-ZIKV, -DENV, and -YFV IgM, against a panel of samples positive for dengue, zika, yellow fever, Rocio, Ilheus, Saint Louis encephalitis, West Nile and c...
Source: Journal of Virological Methods - Category: Virology Authors: Tags: J Virol Methods Source Type: research
by Tyler M. Sharp, Talia M. Quandelacy, Laura E. Adams, Jomil Torres Aponte, Matthew J. Lozier, Kyle Ryff, Mitchelle Flores, Aidsa Rivera, Gilberto A. Santiago, Jorge L. Mu ñoz-Jordán, Luisa I. Alvarado, Vanessa Rivera-Amill, Myriam Garcia-Negrón, Stephen H. Waterman, Gabriela Paz-Bailey, Michael A. Johansson, Brenda Rivera-Garcia BackgroundAfter Zika virus (ZIKV) emerged in the Americas, laboratory-based surveillance for arboviral diseases in Puerto Rico was adapted to include ZIKV disease. Methods and findingsSuspected cases of arboviral disease reported to Puerto Rico Department of Health were teste...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
DISCUSSION: The paper discusses the impact of human activities on landscape and its effects on mosquito populations, focusing on the segregation of different known vector species and their proximity to human altered environments. Most of these species are known arbovirus vectors and knowledge of their distribution are key elements that health authorities should take into account when planning arbovirus surveillance and vector control activities. PMID: 32971068 [PubMed - as supplied by publisher]
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Abstract Viruses were identified from male anthropophilic mosquitoes from Mato Grosso (MT) State, Midwest Brazil from February 2017 to January 2018. Mosquitoes tested included Aedes (Stegomyia) aegypti (1139 males; 84 pools), Culex quinquefasciatus (9426 males; 179 pools), Culex sp. (3 males; 3 pools) and Psorophora albigenu (1 male; 1 pool) collected from four cities of MT. Pools were subjected to viral RNA extraction followed by RT-PCRs specific for ten flaviviruses, five alphaviruses and Simbu serogroup of orthobunyaviruses. Positive pools were passaged three times in VERO cells (alphavirus and orthobunyavirus)...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
Background: Chikungunya (CHIKV), dengue and zika share similar symptoms, which makes a clinical diagnosis complex in regions where the three arboviruses co-circulate. We evaluated the accuracy of the World Health Organization's (WHO) CHIKV case definition against the gold standard of laboratory diagnosis, in individuals with suspicion of arboviral illness seeking care in an urban emergency department (ED) in Rio de Janeiro, Brazil, from January –June 2018.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0635 Source Type: research
Background: From 1995 till 2019, around 147,200 cases of dengue infection and more than 800 deaths are reported from Pakistan. Vector of dengue virus is mosquito Aedes which is capable of transmitting other viral infections like Chikungunya, Zika, and Yellow Fever. From 2016 –2018, Chikungunya infection was reported in 776 patients. With exponential increase in population and utilization of resources, it is important to eradicate this mosquito.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0631 Source Type: research
Background: The dengue virus (DENV) has been in circulation in Brazil for decades, resulting in the occurrence of several outbreaks. The emergence of Chikungunya virus (CHIKV) in 2014 and Zika virus (ZIKV) in 2015 has raised new concerns raised about the prevalence of these arboviruses. Concurrent outbreaks of DENV, CHIKV and ZIKV have taken place in Brazil since 2015, notably in major cities throughout the country's northeastern region. While the state of Bahia has been heavily affected by CHIKV and ZIKV outbreaks, the true burden of these infections remains hidden due to the predominance of asymptomatic infection.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0584 Source Type: research
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