Mitochondria Regulate Inflammatory Paracrine Signalling in Neurodegeneration

AbstractMitochondrial dysfunction occurs in most neurodegenerative diseases, contributing  to both their onset and progression. A recent breakthrough unveiled that propagation of the inflammatory response and subsequent neuronal injury are also mediated extracellularly by damaged mitochondria, which are released from active microglial cells into the brain milieu. These extracellular  fragmented mitochondria can therefore generate sufficient toxicity to trigger neuronal death and widespread brain damage through activation of naïve astrocytes. Besides suggesting potential new pharmacological strategies of therapeutic intervention in neurodegeneration, this original work indica tes that mitochondria might act as bioactive ligands exerting paracrine functions. This is an interesting, novel and impactful concept that deserves consideration by the scientific community, as the attention should now be focused on the identification of the specific receptors through which mitoc hondria mediate such an important extracellular signalling mechanism in neurological conditions.
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research