Cancers, Vol. 12, Pages 2600: Jagged Ligands Enhance the Pro-Angiogenic Activity of Multiple Myeloma Cells

Cancers, Vol. 12, Pages 2600: Jagged Ligands Enhance the Pro-Angiogenic Activity of Multiple Myeloma Cells Cancers doi: 10.3390/cancers12092600 Authors: Maria Teresa Palano Domenica Giannandrea Natalia Platonova Germano Gaudenzi Monica Falleni Delfina Tosi Elena Lesma Valentina Citro Michela Colombo Ilaria Saltarella Roberto Ria Nicola Amodio Elisa Taiana Antonino Neri Giovanni Vitale Raffaella Chiaramonte Multiple myeloma (MM) is an incurable plasma cell malignancy arising primarily within the bone marrow (BM). During MM progression, different modifications occur in the tumor cells and BM microenvironment, including the angiogenic shift characterized by the increased capability of endothelial cells to organize a network, migrate and express angiogenic factors, including vascular endothelial growth factor (VEGF). Here, we studied the functional outcome of the dysregulation of Notch ligands, Jagged1 and Jagged2, occurring during disease progression, on the angiogenic potential of MM cells and BM stromal cells (BMSCs). Jagged1–2 expression was modulated by RNA interference or soluble peptide administration, and the effects on the MM cell lines’ ability to induce human pulmonary artery cells (HPAECs) angiogenesis or to indirectly increase the BMSC angiogenic potential was analyzed in vitro; in vivo validation was performed on a zebrafish model and MM patients’ BM biopsies. Overall, our results indica...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research