Cancers, Vol. 12, Pages 2604: Molecular Classification of Endometrial Stromal Sarcomas Using RNA Sequencing Defines Nosological and Prognostic Subgroups with Different Natural History
Cancers, Vol. 12, Pages 2604: Molecular Classification of Endometrial Stromal Sarcomas Using RNA Sequencing Defines Nosological and Prognostic Subgroups with Different Natural History
Cancers doi: 10.3390/cancers12092604
Authors:
Mehdi Brahmi
Tatiana Franceschi
Isabelle Treilleux
Daniel Pissaloux
Isabelle Ray-Coquard
Armelle Dufresne
Helene Vanacker
Melodie Carbonnaux
Pierre Meeus
Marie-Pierre Sunyach
Amine Bouhamama
Marie Karanian
Alexandra Meurgey
Jean-Yves Blay
Franck Tirode
A series of 42 patient tumors diagnosed as endometrial stromal sarcoma (ESS) based on the morphology but negative for JAZF1 and/or YWHAE rearrangement in FISH was analyzed by RNA-sequencing. A chromosomal rearrangement was identified in 31 (74%) of the cases and a missense mutation in known oncogenes/tumor suppressor genes in 11 (26%). Cluster analyses on the expression profiles from this series together with a control cohort composed of five samples of low grade ESS harboring a JAZF1-SUZ12 fusion, one high grade ESS harboring a BCOR-ITD, two uterine tumors resembling ovarian sex cord tumors, two samples each of uterine leiomyoma and leiomyosarcomas and a series of BCOR-rearranged family of tumor (n = 8) indicated that tumors could be gather in three distinct subgroups: one mainly composed of BCOR-rearranged samples that contained seven ESS samples, one mainly composed of JAZF1-fused ESS (n = 15) and the last composed of various molecular subtypes (n = 19). These thr...
Source: Cancers - Category: Cancer & Oncology Authors: Mehdi Brahmi Tatiana Franceschi Isabelle Treilleux Daniel Pissaloux Isabelle Ray-Coquard Armelle Dufresne Helene Vanacker Melodie Carbonnaux Pierre Meeus Marie-Pierre Sunyach Amine Bouhamama Marie Karanian Alexandra Meurgey Jean-Yves Blay Franck Tirode Tags: Article Source Type: research
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