Population pharmacokinetics of mycophenolic acid in pediatric patients with juvenile dermatomyositis and optimization of limited sampling strategy.

This study aimed to develop a population pharmacokinetic (PPK) model of MPA in children with juvenile dermatomyositis (JDM) and optimize the limited sampling strategy (LSS).Fifteen JDM patients treated with MMF, at a median age of 7.35 (range, 3.09 - 16.1) years, were included. Blood samples were collected at 30 minutes pre-dose, 20 minutes, 60 minutes, and 180 minutes post-dose to measure the MPA concentrations. Data were retrospectively collected from the electronic medical records. A two-compartment model with first-order absorption, lag time in absorption, and first-order elimination was developed. Height and co-administered cotrimoxazole were added as the covariates to the model.Concentrations at different time points were simulated and area under the concentration-time curve (AUC0-12h) was calculated. By removing one sampling point at a time, AUC0-12h from 3-point sampling strategy was re-calculated via Bayesian approach. AUC0-12h from the 3-point sampling strategy (by removing the point at 20 minutes post-dose) had the strongest correlation with AUC0-12h from the 4-point sampling strategy (Pearson's r = 0.971). PMID: 32903096 [PubMed - as supplied by publisher]
Source: Xenobiotica - Category: Research Authors: Tags: Xenobiotica Source Type: research