DNA methylation of hypertension-related genes and effect of riboflavin supplementation in adults stratified by genotype for the MTHFR C677T polymorphism

The interaction between genetic, epigenetic and environmental factors plays an important role in the aetiology of hypertension. GWAS and observational studies link the C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) with hypertension, while riboflavin, the MTHFR cofactor, has been shown to reduce blood pressure and global DNA methylation in homozygous (TT genotype) individuals. It is currently unclear whether riboflavin modulates DNA methylation of other hypertension-related genes.

Source: International Journal of Cardiology - September 9, 2020 Category: Cardiology Authors: Sophia D. Amenyah, Mary Ward, Amy McMahon, Jennifer Deane, Helene McNulty, Catherine Hughes, J.J. Strain, Geraldine Horigan, John Purvis, Colum P. Walsh, Diane J. Lees-Murdock Source Type: research